The role of profilin-1 in cardiovascular diseases | Zendy

Abigail Allen | Zendy; David Gau | Zendy; Partha Roy | Zendy

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The role of profilin-1 in cardiovascular diseases

Author(s) -

Abigail Allen,

David Gau,

Partha Roy

Publication year - 2021

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.249060

Subject(s) - biology , profilin , computational biology , genetics , actin cytoskeleton , cytoskeleton , cell

Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response. An altered actin cytoskeleton is a structural hallmark associated with numerous pathologies ranging from cardiovascular diseases to immune disorders, neurological diseases and cancer. The actin cytoskeleton in cells is regulated through the orchestrated actions of a myriad of actin-binding proteins. In this Review, we provide a brief overview of the structure and functions of the actin-monomer-binding protein profilin-1 (Pfn1) and then discuss how dysregulated expression of Pfn1 contributes to diseases associated with the cardiovascular system.

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