The cell biology behind the oncogenic PIP3 lipids | Zendy

Ana C. Carrera | Zendy; Richard B. Anderson | Zendy

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The cell biology behind the oncogenic PIP3 lipids

Author(s) -

Ana C. Carrera,

Richard B. Anderson

Publication year - 2019

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.228395

Subject(s) - biology , pi3k/akt/mtor pathway , pten , cancer research , cancer , microbiology and biotechnology , genetics , signal transduction

The different mechanisms of phosphoinositide 3-kinase (PI3K) activation in cancer as well as the events that result in PI3K pathway reactivation after patient treatment with PI3K inhibitors was discussed on October 15–17th, 2018, in the medieval town of Baeza (Universidad Internacional de Andalucía, Spain) at the workshop entitled ‘The cell biology behind the oncogenic PIP3 lipids’. These topics and the data presented regarding cellular functions altered by PI3K deregulation, the cooperation of PI3K/PTEN mutations with other tumor drivers, and the lessons learned for PI3K-targeted therapy, are discussed below.

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