p63-related signaling at a glance | Zendy

Matthew L. Fisher | Zendy; Seamus Balinth | Zendy; Alea A. Mills | Zendy

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p63-related signaling at a glance

Author(s) -

Matthew L. Fisher,

Seamus Balinth,

Alea A. Mills

Publication year - 2020

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.228015

Subject(s) - biology , gene isoform , transcription factor , signal transduction , microbiology and biotechnology , cell fate determination , programmed cell death , computational biology , genetics , gene , apoptosis

p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article and the accompanying poster, we focus on the signaling cascades regulating TAp63 and ΔNp63 isoforms and those that are regulated by TAp63 and ΔNp63, as well the role of p63 in disease.

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