Sulphur in epidermal keratohyalin granules: A quantitative assay by x-ray microanalysis | Zendy

H. Jessen | Zendy; P. D. Peters | Zendy; T. A. Hall | Zendy

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Sulphur in epidermal keratohyalin granules: A quantitative assay by x-ray microanalysis

Author(s) -

H. Jessen,

P. D. Peters,

T. A. Hall

Publication year - 1976

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.22.1.161

Subject(s) - epidermis (zoology) , biology , granule (geology) , sulfur , microanalysis , electron microscope , cytoplasm , pathology , biophysics , biochemistry , anatomy , chemistry , medicine , paleontology , physics , organic chemistry , optics

The elemental composition of different types of keratohyalin granules from the epidermis of newborn and adult rats was studied by means of an EMMA-4 analytical electron microscope, equipped with an energy-dispersive X-ray spectrometer. An absolute quantitation of the sulphur concentration in keratohyalin granules was performed. The results demonstrate that epidermal keratohyalin granules are chemically heterogeneous. A type of keratohyalin granule present in the nuclei and cytoplasm of epidermal cells from both newborn and adult rats - termed single granules - is rich in sulphur, having a content of 2-5-3-6%. Other types of keratohyalin granules, which differ in newborn and adult rats, contain a sulphur-poor component; they often have a sulphur-rich component as well. The sulphur-poor keratohyalin contains 0-6-0-9% sulphur. It is suggested that the sulphur-rich keratohyalin granules are the source of the peripheral envelope protein of cornified cells.

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