cis and trans regulation of tissue-specific transcription | Zendy

James Douglas Engel | Zendy; Hartmut Beug | Zendy; Jennifer H. LaVail | Zendy; Martin Zenke | Zendy; Kelly E. Mayo | Zendy; Mark Leonard | Zendy; Kevin P. Foley | Zendy; Zhi Yang | Zendy; Jon M. Kornhauser | Zendy; Liwen Ko | Zendy; Kristen Lim | Zendy; Kathleen M. George | Zendy; K. Breigél | Zendy

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cis and trans regulation of tissue-specific transcription

Author(s) -

James Douglas Engel,

Hartmut Beug,

Jennifer H. LaVail,

Martin Zenke,

Kelly E. Mayo,

Mark Leonard,

Kevin P. Foley,

Zhi Yang,

Jon M. Kornhauser,

Liwen Ko,

Kristen Lim,

Kathleen M. George,

K. Breigél

Publication year - 1992

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.1992.supplement_16.4

Subject(s) - biology , enhancer , transcription factor , gene , regulatory sequence , genetics , regulation of gene expression , transcriptional regulation , promoter , transcription (linguistics) , globin , gene family , gene expression , microbiology and biotechnology , linguistics , philosophy

Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulation. We show here that the chicken adult beta-globin gene promoter sequences are intimately involved in competitive interaction with the beta/epsilon-globin enhancer to regulate differentially epsilon- versus beta-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in a variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well as potential mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities.

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