Platelet-derived growth factor: mechanism of action and relation to oncogenes | Zendy

CarlHenrik Heldin | Zendy; Christer Betsholtz | Zendy; A. Johnsson | Zendy; M. Nistér | Zendy; Bo Ek | Zendy; Lars Rönnstrand | Zendy; Åke Wasteson | Zendy; Bengt Westermark | Zendy

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Platelet-derived growth factor: mechanism of action and relation to oncogenes

Author(s) -

CarlHenrik Heldin,

Christer Betsholtz,

A. Johnsson,

M. Nistér,

Bo Ek,

Lars Rönnstrand,

Åke Wasteson,

Bengt Westermark

Publication year - 1985

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.1985.supplement_3.7

Subject(s) - biology , mechanism (biology) , relation (database) , growth factor , platelet derived growth factor , mechanism of action , action (physics) , factor (programming language) , microbiology and biotechnology , platelet , cancer research , genetics , immunology , platelet derived growth factor receptor , receptor , epistemology , in vitro , philosophy , physics , quantum mechanics , database , computer science , programming language

Recent studies of platelet-derived growth factor (PDGF) have revealed several structural and functional similarities between this growth factor or components linked to its mechanism of action and certain oncogene products: PDGF itself has a structural homology with the transforming protein of simian sarcoma virus, the PDGF receptor has a functional homology (tyrosine kinase activity) with a family of oncogene products, and PDGF induces the expression of the cellular counterparts of myc and fos. In addition, several tumour cell lines have been found to produce PDGF-like growth factors, which may cause autocrine stimulation of growth. We interpret these findings as indicating that regulatory components along the PDGF-dependent mitogenic pathway may have oncogenic properties if they are inappropriately expressed or activated.

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