Elastic fibres | Zendy

Cay M. Kielty | Zendy; Michael J. Sherratt | Zendy; C. Adrian Shuttleworth | Zendy

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Elastic fibres

Author(s) -

Cay M. Kielty,

Michael J. Sherratt,

C. Adrian Shuttleworth

Publication year - 2002

Publication title -

journal of cell science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.115.14.2817

Subject(s) - elastin , fibrillin , biology , extracellular matrix , elasticity (physics) , ultrastructure , connective tissue , microbiology and biotechnology , biophysics , anatomy , materials science , composite material , genetics

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as blood vessels, lungs and skin with the critical properties of elasticity and resilience. The biology of elastic fibres is complex because they have multiple components, a tightly regulated developmental deposition, a multi-step hierarchical assembly and unique biomechanical functions. However, their molecular complexity is at last being unravelled by progress in identifying interactions between component molecules, ultrastructural analyses and studies of informative mouse models.

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