Roles of phospholipid signaling in chemoattractant-induced responses | Zendy

Dianqing Wu | Zendy; ChiKuang Huang | Zendy; Huiping Jiang | Zendy

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Roles of phospholipid signaling in chemoattractant-induced responses

Author(s) -

Dianqing Wu,

ChiKuang Huang,

Huiping Jiang

Publication year - 2000

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.113.17.2935

Subject(s) - chemotaxis , phosphatidylinositol , biology , phospholipase c , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway , chemokine , beta (programming language) , phosphorylation , phosphoinositide phospholipase c , kinase , phospholipase d , phospholipase , biochemistry , enzyme , receptor , computer science , programming language

Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamma) demonstrate that chemoattractants act through PLC-(beta)2 and PLC-(beta)3 to hydrolyze PtdIns(4,5)P(2) and through PI3K(gamma) to phosphorylate PtdIns(4,5)P(2) in mouse neutrophils. These studies also confirmed the importance and revealed new roles of these signaling pathways in chemoattractant-induced responses.

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