Open Accessp53 at a glance
Author(s) -
Colleen A. Brady,
Laura D. Attardi
Publication year - 2010
Publication title -
journal of cell science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.384
H-Index - 278
eISSN - 1477-9137
pISSN - 0021-9533
DOI - 10.1242/jcs.064501
Subject(s) - biology , autophagy , suppressor , tumor suppressor gene , cancer , apoptosis , cell cycle , cell cycle checkpoint , disease , cancer research , neuroscience , microbiology and biotechnology , genetics , carcinogenesis , medicine
Since its discovery in 1979, the role of the p53 protein in cancer has been studied intensively ([Levine and Oren, 2009][1]). p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of different
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