MicroRNAs in human cancer: from research to therapy | Zendy

Massimo Negrini | Zendy; Manuela Ferracin | Zendy; Silvia Sabbioni | Zendy; Carlo M. Croce | Zendy

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MicroRNAs in human cancer: from research to therapy

Author(s) -

Massimo Negrini,

Manuela Ferracin,

Silvia Sabbioni,

Carlo M. Croce

Publication year - 2007

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.03450

Subject(s) - biology , microrna , epigenetics , gene , dna methylation , suppressor , cancer , genetics , computational biology , encode , methylation , cancer research , gene expression

Numerous miRNAs are deregulated in human cancers, and experimental evidence indicates that they can play roles as oncogenes or tumor suppressor genes. Similarly to cancer genes that encode proteins, deregulation of miRNA-encoding genes is associated with genetic or epigenetic alterations, such as deletions, amplifications, point mutations and aberrant DNA methylation. The discovery that miRNAs interact with known oncogenes has established further links with molecular pathways implicated in malignant transformation. Finally, miRNAs can be used as diagnostic markers, and their potential as therapeutic molecules has moved miRNAs from the area of basic research to the field of cancer biotechnology.

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