Wnt signalling: variety at the core | Zendy

Stefan Hoppler | Zendy; Claire Kavanagh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Wnt signalling: variety at the core

Author(s) -

Stefan Hoppler,

Claire Kavanagh

Publication year - 2007

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.03363

Subject(s) - biology , wnt signaling pathway , alternative splicing , embryonic stem cell , microbiology and biotechnology , gene isoform , rna splicing , gene , genetics , cellular differentiation , rna

The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research