Open AccessControl of mitochondrial apoptosis by the Bcl-2 family
Author(s) -
Joslyn K. Brunelle,
Anthony Letai
Publication year - 2009
Publication title -
journal of cell science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.384
H-Index - 278
eISSN - 1477-9137
pISSN - 0021-9533
DOI - 10.1242/jcs.031682
Subject(s) - biology , apoptosis , bcl 2 family , microbiology and biotechnology , caenorhabditis elegans , programmed cell death , mitochondrion , intrinsic apoptosis , bcl 2 associated x protein , protein family , caspase , genetics , gene , caspase 3
Programmed cell death, or apoptosis, is important for the development and homeostasis of tissues. Too little cell death can result in autoimmune diseases or cancer, whereas excessive cell death can lead to debilitating degenerative diseases of the heart or nervous system. The realization that
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