Dynamin as a mover and pincher during cell migration and invasion | Zendy

Anne Kruchten | Zendy; Mark A. McNiven | Zendy

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Dynamin as a mover and pincher during cell migration and invasion

Author(s) -

Anne Kruchten,

Mark A. McNiven

Publication year - 2006

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.02963

Subject(s) - dynamin , biology , endocytosis , gtpase , microbiology and biotechnology , focal adhesion , actin , motility , cell migration , cell adhesion , cell , signal transduction , biochemistry

The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.

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