Signaling networks in aging | Zendy

Eric Lieberman Greer | Zendy; Anne Brunet | Zendy

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Signaling networks in aging

Author(s) -

Eric Lieberman Greer,

Anne Brunet

Publication year - 2008

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.021519

Subject(s) - biology , insulin receptor , longevity , drosophila melanogaster , caenorhabditis elegans , pi3k/akt/mtor pathway , foxo1 , signal transduction , genetics , genetic screen , transcription factor , insulin , irs1 , protein kinase b , microbiology and biotechnology , gene , endocrinology , mutant , insulin resistance

Aging – long considered to be solely the result of wear and tear – is in fact regulated by specific genetic pathways. Simple changes in the environment (e.g. dietary restriction) can drastically extend lifespan, suggesting that several of these genetic pathways control longevity in response to

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