TOR signaling in mammals | Zendy

Ana C. Carrera | Zendy

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TOR signaling in mammals

Author(s) -

Ana C. Carrera

Publication year - 2004

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.01311

Subject(s) - p70 s6 kinase 1 , biology , ribosomal protein s6 , pi3k/akt/mtor pathway , eif4e , tor signaling , mechanistic target of rapamycin , ribosome biogenesis , microbiology and biotechnology , mtorc2 , eukaryotic initiation factor , eukaryotic translation , rptor , translation (biology) , ribosomal protein , ribosomal s6 kinase , mtorc1 , ribosome , signal transduction , biochemistry , messenger rna , rna , gene

Central to the pathways that induce cell growth in mammals is the murine target of rapamycin (mTOR), a multi-domain, 298 kDa, evolutionarily-conserved Ser/Thr kinase that is inhibited by the drug rapamycin ([Schmelzle and Hall, 2000][1]). mTOR exerts its effects by phosphorylating eukaryotic

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