Open AccessAntibiotics acting on the translational machinery
Author(s) -
J. Harms,
Heike Bartels,
Frank Schlünzen,
Ada Yonath
Publication year - 2003
Publication title -
journal of cell science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.384
H-Index - 278
eISSN - 1477-9137
pISSN - 0021-9533
DOI - 10.1242/jcs.00365
Subject(s) - biology , antibiotics , computational biology , microbiology and biotechnology
Despite the appearance of bacterial strains resistant to all clinical antibiotics, including vancomycin (the `last resort'), development of new antimicrobial agents has slowed during recent decades. To aid design of new antibiotics, we must develop a detailed understanding of the mechanisms of
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