Modeling hematopoietic disorders in zebrafish | Zendy

Martina Konantz | Zendy; Christoph Schürch | Zendy; Pauline Hanns | Zendy; Joëlle S. Müller | Zendy; Loïc Sauteur | Zendy; Claudia Lengerke | Zendy

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Modeling hematopoietic disorders in zebrafish

Author(s) -

Martina Konantz,

Christoph Schürch,

Pauline Hanns,

Joëlle S. Müller,

Loïc Sauteur,

Claudia Lengerke

Publication year - 2019

Publication title -

disease models and mechanisms

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.327

H-Index - 83

eISSN - 1754-8411

pISSN - 1754-8403

DOI - 10.1242/dmm.040360

Subject(s) - zebrafish , biology , haematopoiesis , myeloid , computational biology , genetic model , vertebrate , animal model , model organism , bone marrow , fish <actinopterygii> , neuroscience , microbiology and biotechnology , immunology , stem cell , genetics , gene , endocrinology , fishery

Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.

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