HSV presence in brains of individuals without dementia: the TASTY brain series | Zendy

Jan Olsson | Zendy; Hugo Lövheim | Zendy; Emma Honkala | Zendy; Pekka J. Karhunen | Zendy; Fredrik Elgh | Zendy; Eloise Kok | Zendy

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HSV presence in brains of individuals without dementia: the TASTY brain series

Author(s) -

Jan Olsson,

Hugo Lövheim,

Emma Honkala,

Pekka J. Karhunen,

Fredrik Elgh,

Eloise Kok

Publication year - 2016

Publication title -

disease models and mechanisms

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.327

H-Index - 83

eISSN - 1754-8411

pISSN - 1754-8403

DOI - 10.1242/dmm.026674

Subject(s) - dementia , series (stratigraphy) , neuroscience , psychology , biology , medicine , paleontology , disease

Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (Aβ) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had Aβ aggregations, most of those with Aβ aggregations did not have HSV present in the brain tissue.

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