Open AccessEarly loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al.
Author(s) -
Dongsheng Duan,
Chady H. Hakim,
Carlos Eduardo Ambrósio,
B. F. Smith,
H. Lee Sweeney
Publication year - 2015
Publication title -
disease models and mechanisms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.327
H-Index - 83
eISSN - 1754-8411
pISSN - 1754-8403
DOI - 10.1242/dmm.019216
Subject(s) - duchenne muscular dystrophy , dystrophin , medicine , muscular dystrophy , myopathy , disease , natural history
Dystrophin-deficient dogs are the most commonly used large animal model for Duchenne muscular dystrophy (DMD), a lethal muscle disease currently without an effective therapy. Tremendous progress has been made over the last few years in the development of novel pharmacological and genetic therapies
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