Open AccessVascular homeostasis: insights from a fibrotic mouse
Author(s) -
Stephen P. Santoro,
Nancy L. Maas
Publication year - 2010
Publication title -
disease models and mechanisms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.327
H-Index - 83
eISSN - 1754-8411
pISSN - 1754-8403
DOI - 10.1242/dmm.006726
Subject(s) - extracellular matrix , matrix metalloproteinase , vascular permeability , protease , collagenase , in vivo , microbiology and biotechnology , proteases , chemistry , homeostasis , biology , cancer research , biochemistry , enzyme , endocrinology
Efficient delivery of cancer chemotherapeutic agents depends on the permeability of the tumor vasculature. The natural hyperpermeability of tumor vessels increases absorption of macromolecular drugs into tumor tissue, suggesting that further enhancement of this process could be beneficial to the
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