Open AccessThe skinny on SIRT1 regulation
Author(s) -
Thaddeus T. Schug
Publication year - 2010
Publication title -
disease models and mechanisms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.327
H-Index - 83
eISSN - 1754-8411
pISSN - 1754-8403
DOI - 10.1242/dmm.005629
Subject(s) - biology
SIRT1 (sirtuin 1), the mammalian orthologue of yeast Sir2, is a highly conserved NAD+-dependant deacetylase that is emerging as an important regulator of aging and metabolic disease. SIRT1 and its family members promote longevity in different model organisms, including yeast, worms, flies and mice.
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