The in vivo behaviour of achondroplastic cartilage from the cartilage anomaly (can/can) mouse | Zendy

David R. Johnson | Zendy

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The in vivo behaviour of achondroplastic cartilage from the cartilage anomaly (can/can) mouse

Author(s) -

David R. Johnson

Publication year - 1974

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.31.2.313

Subject(s) - cartilage , biology , in vivo , achondroplasia , in vitro , anatomy , endocrinology , biochemistry , genetics

Explanted cartilage from can/can mice aged 3 days shows increased protein and mucopolysaccharide synthesis. Injection of [U-14C]glucose into 3-day-old can/can mice failed to duplicate the increased mucopolysaccharide formation. Transplanted can/can tail vertebrae grown in the renal capsule of normal sibs grew less well than those from normal litter-mates, also suggesting that the increased metabolism seen in vitro is not a feature of in vivo development.

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