Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies | Zendy

Keishi Kishimoto | Zendy; Mitsuru Morimoto | Zendy

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Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies

Author(s) -

Keishi Kishimoto,

Mitsuru Morimoto

Publication year - 2021

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.198192

Subject(s) - biology , tracheomalacia , morphogenesis , induced pluripotent stem cell , microbiology and biotechnology , tracheoesophageal fistula , stem cell , in vivo , anatomy , pathology , embryonic stem cell , airway , genetics , esophagus , surgery , medicine , gene

The trachea delivers inhaled air into the lungs for gas exchange. Anomalies in tracheal development can result in life-threatening malformations, such as tracheoesophageal fistula and tracheomalacia. Given the limitations of current therapeutic approaches, development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review, recent advances in mammalian tracheal development and the generation of tracheal tissues from pluripotent stem cells are summarized.

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