The origin and mechanisms of smooth muscle cell development in vertebrates | Zendy

Michael Donadon | Zendy; Massimo Santoro | Zendy

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The origin and mechanisms of smooth muscle cell development in vertebrates

Author(s) -

Michael Donadon,

Massimo Santoro

Publication year - 2021

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.197384

Subject(s) - biology , organogenesis , vertebrate , regeneration (biology) , microbiology and biotechnology , myocyte , embryonic stem cell , anatomy , process (computing) , smooth muscle , smooth muscle tissue , cell , neuroscience , gene , genetics , endocrinology , computer science , operating system

Smooth muscle cells (SMCs) represent a major structural and functional component of many organs during embryonic development and adulthood. These cells are a crucial component of vertebrate structure and physiology, and an updated overview of the developmental and functional process of smooth muscle during organogenesis is desirable. Here, we describe the developmental origin of SMCs within different tissues by comparing their specification and differentiation with other organs, including the cardiovascular, respiratory and intestinal systems. We then discuss the instructive roles of smooth muscle in the development of such organs through signaling and mechanical feedback mechanisms. By understanding SMC development, we hope to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.

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