The roles of TET family proteins in development and stem cells | Zendy

Jihong Yang | Zendy; Nazym Bashkenova | Zendy; Ruge Zang | Zendy; Xin Huang | Zendy; Jianlong Wang | Zendy

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The roles of TET family proteins in development and stem cells

Author(s) -

Jihong Yang,

Nazym Bashkenova,

Ruge Zang,

Xin Huang,

Jianlong Wang

Publication year - 2020

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.183129

Subject(s) - biology , dna demethylation , epigenetics , dna methylation , embryonic stem cell , 5 methylcytosine , stem cell , microbiology and biotechnology , 5 hydroxymethylcytosine , gene , cellular differentiation , demethylation , regulation of gene expression , dna , gene expression , genetics

Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.

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