The hope and the hype of organoid research | Zendy

Meritxell Huch | Zendy; Juergen A. Knoblich | Zendy; Matthias P. Lütolf | Zendy; Alfonso Martínez Arias | Zendy

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The hope and the hype of organoid research

Author(s) -

Meritxell Huch,

Juergen A. Knoblich,

Matthias P. Lütolf,

Alfonso Martínez Arias

Publication year - 2017

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.150201

Subject(s) - organoid , enthusiasm , biology , scientific discovery , translational research , data science , engineering ethics , computational biology , neuroscience , computer science , cognitive science , microbiology and biotechnology , engineering , psychology , social psychology

The recent increase in organoid research has been met with great enthusiasm, as well as expectation, from the scientific community and the public alike. There is no doubt that this technology opens up a world of possibilities for scientific discovery in developmental biology as well as in translational research, but whether organoids can truly live up to this challenge is, for some, still an open question. In this Spotlight article, Meritxell Huch and Juergen Knoblich begin by discussing the exciting promise of organoid technology and give concrete examples of how this promise is starting to be realised. In the second part, Matthias Lutolf and Alfonso Martinez-Arias offer a careful and considered view of the state of the organoid field and its current limitations, and lay out the approach they feel is necessary to maximise the potential of organoid technology.

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