Prostate organogenesis: tissue induction, hormonal regulation and cell type specification | Zendy

Roxanne Toivanen | Zendy; Michael M. Shen | Zendy

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Prostate organogenesis: tissue induction, hormonal regulation and cell type specification

Author(s) -

Roxanne Toivanen,

Michael M. Shen

Publication year - 2017

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.148270

Subject(s) - organogenesis , biology , mesenchyme , prostate , morphogenesis , prostate cancer , hormone , carcinogenesis , microbiology and biotechnology , endocrinology , cancer , genetics , mesenchymal stem cell , gene

Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.

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