Translational applications of adult stem cell-derived organoids | Zendy

Jarno Drost | Zendy; Hans Clevers | Zendy

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Translational applications of adult stem cell-derived organoids

Author(s) -

Jarno Drost,

Hans Clevers

Publication year - 2017

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.140566

Subject(s) - organoid , biology , stem cell , regenerative medicine , adult stem cell , microbiology and biotechnology , in vitro , endothelial stem cell , genetics

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

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