Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination | Zendy

Jason Yu | Zendy; Wei Cui | Zendy

Open Access

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

Author(s) -

Jason Yu,

Wei Cui

Publication year - 2016

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.137075

Subject(s) - pi3k/akt/mtor pathway , biology , protein kinase b , microbiology and biotechnology , rptor , proto oncogene proteins c akt , context (archaeology) , induced pluripotent stem cell , mtorc2 , kinase , signal transduction , embryonic stem cell , mtorc1 , genetics , paleontology , gene

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies - in particular those using pluripotent stem cells - have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.

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