Slit-Robo signaling | Zendy

Heike Blockus | Zendy; Alain Chédotal | Zendy

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Slit-Robo signaling

Author(s) -

Heike Blockus,

Alain Chédotal

Publication year - 2016

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.132829

Subject(s) - slit , roundabout , biology , axon guidance , crosstalk , receptor , signal transduction , microbiology and biotechnology , nervous system , neurogenesis , axon , neuroscience , genetics , physics , optics

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.

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