The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis | Zendy

Timm Haack | Zendy; Salim AbdelilahSeyfried | Zendy

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The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Author(s) -

Timm Haack,

Salim AbdelilahSeyfried

Publication year - 2016

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.131425

Subject(s) - endocardium , mechanotransduction , biology , heart development , morphogenesis , embryonic heart , microbiology and biotechnology , mammalian heart , embryonic stem cell , reprogramming , hedgehog signaling pathway , anatomy , signal transduction , medicine , cell , genetics , gene

Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flow-responsive endocardial signalling can result in pathophysiological changes.

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