When stem cells grow old: phenotypes and mechanisms of stem cell aging | Zendy

Michael Schultz | Zendy; David Sinclair | Zendy

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When stem cells grow old: phenotypes and mechanisms of stem cell aging

Author(s) -

Michael Schultz,

David Sinclair

Publication year - 2016

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.130633

Subject(s) - biology , stem cell , stem cell theory of aging , multicellular organism , phenotype , adult stem cell , microbiology and biotechnology , haematopoiesis , germline , hematopoietic stem cell , neuroscience , cell , cellular differentiation , immunology , stem cell factor , genetics , gene

All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and germline. Here, we discuss recent advances in our understanding of why adult stem cells age and how this aging impacts diseases and lifespan. With this increased understanding, it is feasible to design and test interventions that delay stem cell aging and improve both health and lifespan.

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