A zinc finger protein that regulates oligodendrocyte specification, migration, and myelination in zebrafish | Zendy

Harwin Sidik | Zendy; William S. Talbot | Zendy

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A zinc finger protein that regulates oligodendrocyte specification, migration, and myelination in zebrafish

Author(s) -

Harwin Sidik,

William S. Talbot

Publication year - 2015

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.128215

Subject(s) - biology , zebrafish , oligodendrocyte , myelin , myelin basic protein , zinc finger , mutant , microbiology and biotechnology , central nervous system , neuroscience , genetics , gene , transcription factor

Precise control of oligodendrocyte migration and development is crucial for myelination of axons in the central nervous system (CNS), but important questions remain unanswered about the mechanisms controlling these processes. In a zebrafish screen for myelination mutants, we identified a mutation in zinc finger protein 16-like (znf16l). znf16l mutant larvae have reduced myelin basic protein (mbp) expression and reduced CNS myelin. Marker, time-lapse and ultrastructural studies indicated that oligodendrocyte specification, migration and myelination are disrupted in znf16l mutants. Transgenic studies indicated that znf16l acts autonomously in oligodendrocytes. Expression of Zfp488 from mouse rescued mbp expression in znf16l mutants, indicating that these homologs have overlapping functions. Our results defined the function of a new zinc finger protein with specific function in oligodendrocyte specification, migration and myelination in the developing CNS.

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