Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex duringDrosophilaoogenesis | Zendy

Akira Nakamura | Zendy; Reiko Amikura | Zendy; Kazuko Hanyu | Zendy; Satoru Kobayashi | Zendy

Open Access

Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex duringDrosophilaoogenesis

Author(s) -

Akira Nakamura,

Reiko Amikura,

Kazuko Hanyu,

Satoru Kobayashi

Publication year - 2001

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.128.17.3233

Subject(s) - biology , oocyte , ribonucleoprotein , oogenesis , microbiology and biotechnology , rna binding protein , translation (biology) , rna , drosophila melanogaster , cytoplasm , argonaute , genetics , rna interference , messenger rna , gene , embryo

Embryonic patterning in Drosophila is regulated by maternal factors. Many such factors become localized as mRNAs within the oocyte during oogenesis and are translated in a spatio-temporally regulated manner. These processes are controlled by trans-acting proteins, which bind to the target RNAs to form a ribonucleoprotein (RNP) complex. We report that a DEAD-box protein, Me31B, forms a cytoplasmic RNP complex with oocyte-localizing RNAs and Exuperantia, a protein involved in RNA localization. During early oogenesis, loss of Me31B causes premature translation of oocyte-localizing RNAs within nurse cells, without affecting their transport to the oocyte. These results suggest that Me31B mediates translational silencing of RNAs during their transport to the oocyte. Our data provide evidence that RNA transport and translational control are linked through the assembly of RNP complex.

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