Photoreceptor cell fate specification in vertebrates | Zendy

Joseph A. Brzezinski | Zendy; Thomas A. Reh | Zendy

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Photoreceptor cell fate specification in vertebrates

Author(s) -

Joseph A. Brzezinski,

Thomas A. Reh

Publication year - 2015

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.127043

Subject(s) - biology , cell fate determination , vertebrate , induced pluripotent stem cell , progenitor cell , neuroscience , transcription factor , microbiology and biotechnology , cellular differentiation , retina , gene regulatory network , cell type , developmental biology , photoreceptor cell , muller glia , cell , stem cell , gene , embryonic stem cell , genetics , gene expression

Photoreceptors--the light-sensitive cells in the vertebrate retina--have been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. As a result, great progress in understanding the transcriptional network that controls photoreceptor specification and differentiation has been made over the last 20 years. This progress has also enabled the production of photoreceptors from pluripotent stem cells, thereby aiding the development of regenerative medical approaches to eye disease. In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification.

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