Planar cell polarity in moving cells: think globally, act locally | Zendy

Crystal F. Davey | Zendy; Cecilia B. Moens | Zendy

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Planar cell polarity in moving cells: think globally, act locally

Author(s) -

Crystal F. Davey,

Cecilia B. Moens

Publication year - 2017

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.122804

Subject(s) - biology , planar , microbiology and biotechnology , polarity (international relations) , cell , genetics , computer graphics (images) , computer science

The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells within the plane of a tissue but it also plays a role in a range of cell migration events during development. The mechanism by which the PCP pathway polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to regulate more dynamic cell behaviors during directed cell migration is much less understood. Here, we review recent discoveries regarding the localization of PCP proteins in migrating cells and their impact on the cell biology of collective and individual cell migratory behaviors.

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