Human pancreas development | Zendy

Rachel Jennings | Zendy; Andrew Berry | Zendy; James Strutt | Zendy; Dave T. Gerrard | Zendy; Neil A. Hanley | Zendy

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Human pancreas development

Author(s) -

Rachel Jennings,

Andrew Berry,

James Strutt,

Dave T. Gerrard,

Neil A. Hanley

Publication year - 2015

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.120063

Subject(s) - biology , pancreas , induced pluripotent stem cell , embryonic stem cell , diabetes mellitus , bioinformatics , endocrinology , genetics , gene

A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

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