Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo | Zendy

Odile deLapeyrière | Zendy; Vincent Ollendorff | Zendy; J Planche | Zendy; M O Ott | Zendy; Sandrine Pizette | Zendy; François Coulier | Zendy; Daniel Birnbaum | Zendy

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Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo

Author(s) -

Odile deLapeyrière,

Vincent Ollendorff,

J Planche,

M O Ott,

Sandrine Pizette,

François Coulier,

Daniel Birnbaum

Publication year - 1993

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.118.2.601

Subject(s) - biology , myogenesis , skeletal muscle , conceptus , embryo , fibroblast growth factor , myocyte , microbiology and biotechnology , gene expression , gene , in situ hybridization , embryonic stem cell , population , genetics , endocrinology , receptor , pregnancy , gestation , demography , sociology

Fgf6, a member of the Fibroblast Growth Factor (FGF) family, is developmentally regulated and its expression is highly restricted in the adult. To gain further insight into the role of Fgf6, we studied its expression during embryogenesis using RNA in situ hybridization. Fgf6 expression is restricted to developing skeletal muscle. Fgf6 transcripts are first detected in the somites at 9.5 days post-conceptus, and expression continues in developing skeletal muscles up to at least 16.5 days post-conceptus. Fgfr4 is a putative receptor for FGF6. Its pattern of expression during myogenesis overlaps that of Fgf6, but both genes are not expressed in exactly the same population of cells. In addition, recombinant FGF6 protein is able to repress the terminal differentiation of myoblasts in culture, providing additional support to the concept that FGF6 plays an important role in myogenesis.

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