Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis | Zendy

Nancy Jo Pokrywka | Zendy; Edwin C. Stephenson | Zendy

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Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis

Author(s) -

Nancy Jo Pokrywka,

Edwin C. Stephenson

Publication year - 1991

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.113.1.55

Subject(s) - biology , drosophila embryogenesis , morphogen , microtubule , microbiology and biotechnology , rna , rna interference , drosophila melanogaster , genetics , gene

We have examined cytoskeletal requirements for bicoid (bcd) RNA localization during Drosophila oogenesis. bcd is an anterior morphogen whose proper function relies on the localization of its messenger RNA to the anterior cortex of the egg. Drugs that depolymerize microtubules perturb all aspects of bcd RNA localization. During recovery from drug treatment, bcd RNA relocalizes to the oocyte cortex, suggesting that the localization machinery is a component of the cortical cytoskeleton. Taxol, a drug that stabilizes microtubules, also effectively disrupts bcd RNA localization, and the effects of taxol treatments on exuperantia and swallow mutants suggest general roles for these gene products in the multi-step bcd RNA localization process.

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