The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism | Zendy

Moritz Jacobshagen | Zendy; Mathieu Niquille | Zendy; Séverine ChaumontDubel | Zendy; Philippe Marin | Zendy; Alexandre Dayer | Zendy

Open Access

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism

Author(s) -

Moritz Jacobshagen,

Mathieu Niquille,

Séverine ChaumontDubel,

Philippe Marin,

Alexandre Dayer

Publication year - 2014

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.108043

Subject(s) - corticogenesis , neocortex , cyclin dependent kinase 5 , neuroscience , biology , g protein coupled receptor , regulator , neuron , receptor , microbiology and biotechnology , signal transduction , protein kinase c , biochemistry , stem cell , mitogen activated protein kinase kinase , gene , progenitor cell

The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.

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