Open AccessmicroRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons
Author(s) -
Malin Åkerblom,
Rebecca Petri,
Rohit Sachdeva,
Thies Klussendorf,
Bengt Mattsson,
Bernhard Gentner,
Johan Jakobsson
Publication year - 2014
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.15
H-Index - 36
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.101659
Subject(s) - olfactory bulb , biology , subventricular zone , neuroscience , sensory system , neurogenesis , population , microrna , interneuron , olfactory system , neural stem cell , microbiology and biotechnology , central nervous system , inhibitory postsynaptic potential , stem cell , gene , genetics , demography , sociology
New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.
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