How to make a primordial germ cell | Zendy

Erna Magnúsdóttir | Zendy; M. Azim Surani | Zendy

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How to make a primordial germ cell

Author(s) -

Erna Magnúsdóttir,

M. Azim Surani

Publication year - 2013

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.098269

Subject(s) - biology , somatic cell , induced pluripotent stem cell , germ line development , embryonic stem cell , germ , germline , germ cell , microbiology and biotechnology , epigenetics , genetics , reprogramming , epigenesis , cell , dna methylation , gene , gene expression

Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through germ cells. PGCs are specified during early mammalian postimplantation development, and are uniquely programmed for transmission of genetic and epigenetic information to subsequent generations. In this Primer, we summarise the establishment of the fundamental principles of PGC specification during early development and discuss how it is now possible to make mouse PGCs from pluripotent embryonic stem cells, and indeed somatic cells if they are first rendered pluripotent in culture.

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