Stem cell metabolism in tissue development and aging | Zendy

Ng ShyhChang | Zendy; George Q. Daley | Zendy; Lewis C. Cantley | Zendy

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Stem cell metabolism in tissue development and aging

Author(s) -

Ng ShyhChang,

George Q. Daley,

Lewis C. Cantley

Publication year - 2013

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.091777

Subject(s) - biology , stem cell , reprogramming , microbiology and biotechnology , oxidative phosphorylation , metabolomics , somatic cell , regeneration (biology) , oxidative stress , mitochondrion , cell , cellular differentiation , bioinformatics , biochemistry , gene

Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to be a mere consequence of the state of a cell, metabolism is now known to play a pivotal role in dictating whether a cell proliferates, differentiates or remains quiescent. Here, we review recent studies of metabolism in stem cells that have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of adult stem cells, and during the reprogramming of somatic cells to pluripotency. These insights promise to inform strategies for the directed differentiation of stem cells and to offer the potential for novel metabolic or pharmacological therapies to enhance regeneration and the treatment of degenerative disease.

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