A germline-centric view of cell fate commitment, reprogramming and immortality | Zendy

MariaElena TorresPadilla | Zendy; Rafal Ciosk | Zendy

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A germline-centric view of cell fate commitment, reprogramming and immortality

Author(s) -

MariaElena TorresPadilla,

Rafal Ciosk

Publication year - 2013

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.087577

Subject(s) - biology , germline , reprogramming , immortality , embryonic stem cell , somatic cell , cell fate determination , germ cell , microbiology and biotechnology , lineage (genetic) , epigenesis , genetics , evolutionary biology , cell , gene , gene expression , transcription factor , dna methylation

To ensure species continuity, the tantalising developmental plasticity of early embryonic cells, also called totipotency, must be transmitted to the offspring. This responsibility rests within the reproductive cell lineage: the germ line. At the recent EMBO/EMBL symposium 'Germline - Immortality through Totipotency', researchers discussed the mechanisms that establish and control totipotency, with an eye towards the mechanisms that may endow germ cells with the ability to propagate totipotency across generations.

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