Open AccessThe effort to make mosaic analysis a household tool
Author(s) -
Tian Xu,
Gerald M. Rubin
Publication year - 2012
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.15
H-Index - 36
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.085183
Subject(s) - biology , mosaic , set (abstract data type) , computational biology , evolutionary biology , genome , genetics , gene , computer science , history , archaeology , programming language
The analysis of genetic mosaics, in which an animal carries populations of cells with differing genotypes, is a powerful tool for understanding developmental and cell biology. In 1990, we set out to improve the methods used to make genetic mosaics in Drosophila by taking advantage of recently developed approaches for genome engineering. These efforts led to the work described in our 1993 Development paper.
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