Stem cells living with a Notch | Zendy

Ute Koch | Zendy; Rajwinder Lehal | Zendy; Freddy Radtke | Zendy

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Stem cells living with a Notch

Author(s) -

Ute Koch,

Rajwinder Lehal,

Freddy Radtke

Publication year - 2013

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.080614

Subject(s) - biology , notch signaling pathway , stem cell , microbiology and biotechnology , embryonic stem cell , homeostasis , cellular differentiation , cell signaling , cell , adult stem cell , signal transduction , genetics , gene

Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development and control of tissue homeostasis in a variety of adult tissues, and regulates stem cell maintenance, cell differentiation and cellular homeostasis. The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments.

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