The developmental origins of adipose tissue | Zendy

Daniel C. Berry | Zendy; Drew Stenesen | Zendy; Daniel Zeve | Zendy; Jonathan M. Graff | Zendy

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The developmental origins of adipose tissue

Author(s) -

Daniel C. Berry,

Drew Stenesen,

Daniel Zeve,

Jonathan M. Graff

Publication year - 2013

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.080549

Subject(s) - adipose tissue , biology , homeostasis , microbiology and biotechnology , endocrinology

Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.

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