Combinatorial regulation of tissue specification by GATA and FOG factors | Zendy

Timothy M. Chlon | Zendy; John D. Crispino | Zendy

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Combinatorial regulation of tissue specification by GATA and FOG factors

Author(s) -

Timothy M. Chlon,

John D. Crispino

Publication year - 2012

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.080440

Subject(s) - biology , progenitor cell , transcription factor , cell fate determination , microbiology and biotechnology , transcriptional regulation , cell type , cellular differentiation , function (biology) , progenitor , stem cell , regulation of gene expression , gene , gata transcription factor , lineage (genetic) , cell , genetics , computational biology , gene expression , promoter

The development of complex organisms requires the formation of diverse cell types from common stem and progenitor cells. GATA family transcriptional regulators and their dedicated co-factors, termed Friend of GATA (FOG) proteins, control cell fate and differentiation in multiple tissue types from Drosophila to man. FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the factor, cell, and even the specific gene target. In this review, we highlight recent studies that have elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use these diverse modes of gene regulation to control cell lineage specification throughout metazoans.

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