Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain | Zendy

Anju Vasudevan | Zendy; ChungKil Won | Zendy; Suyan Li | Zendy; Ferenc Erdélyi | Zendy; Gábor Szabó | Zendy; Kwangsoo Kim | Zendy

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Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain

Author(s) -

Anju Vasudevan,

ChungKil Won,

Suyan Li,

Ferenc Erdélyi,

Gábor Szabó,

Kwangsoo Kim

Publication year - 2012

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.078394

Subject(s) - midbrain , biology , neuroscience , dopaminergic , embryonic stem cell , neuron , neuronal migration , dopamine , central nervous system , gene , genetics

Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing novel insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon in normal as well as diseased brains.

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