Convergent extension: using collective cell migration and cell intercalation to shape embryos | Zendy

Masazumi Tada | Zendy; CarlPhilipp Heisenberg | Zendy

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Convergent extension: using collective cell migration and cell intercalation to shape embryos

Author(s) -

Masazumi Tada,

CarlPhilipp Heisenberg

Publication year - 2012

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.073007

Subject(s) - convergent extension , biology , elongation , intercalation (chemistry) , embryo , extension (predicate logic) , microbiology and biotechnology , anatomy , biophysics , embryogenesis , gastrulation , materials science , inorganic chemistry , chemistry , ultimate tensile strength , computer science , metallurgy , programming language

Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and extension. Both collective cell migration and cell intercalation are thought to drive CE and are used to different degrees in various species as they elongate their body axis. Here, we provide an overview of CE as a general strategy for body axis elongation and discuss conserved and divergent mechanisms underlying CE among different species.

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